In 2006, one study compared [10] DM1 patients submitted to PTAs and patients kept under intensive insulin therapy, and showed that among non-proliferative retinopathy individuals, there was an even 50% ratio between improvement and stabilization, compared to 20% improvement, 10% stabilization and 70% worsening figures in the control group, under intensive insulin therapy. This evidence concerns the gene INS and retinal disorder.