S100A8 and type 2 diabetes mellitus: As low-grade systemic inflammation is a hallmark of both obesity and type 2 diabetes (T2D) we studied the levels of plasma calprotectin and S100A8 skeletal muscle mRNA levels using a cross-sectional case control design in which patients with T2D and healthy controls were closely matched, not only according to age and sex but also according to body mass index (BMI).