The effect of the inhibition of GSK3 on protein levels of progenitor (Nestin and Sox2) and differentiation (CNPase, GFAP, and β-tubulin III) markers in GBM cell lines U373, LN319, BS125 and LN18 was analyzed using the drugs LiCl and SB216763 or siRNAs. This evidence concerns the gene NES and glioblastoma.