[37] However, since the Y402H variant of CFH confers similar risk of soft drusen and both forms of advanced AMD, it may contribute to the increased risk of advanced AMD largely or entirely through its impact on precursors of visually disabling AMD such as drusen. [38] Since polymorphisms in CFH, C3, and ARMS2 are not associated with progression of GA and since our previous analysis did not detect a significant contribution of other characteristics (including smoking and BMI) [28] other modifying genetic factors may be involved. The gene discussed is C3; the disease is age-related macular degeneration.