In a case-control association analysis (N = 99 cases of pure bilateral GA; N = 612 controls), polymorphisms Y402H (rs1061170) in CFH, A69S (rs10490924) in ARMS2 and R102G (rs2230199) in the C3 gene were strongly associated with GA due to AMD (Table 1). This evidence concerns the gene C3 and age-related macular degeneration.