Concerning FOXF1 and the 16q24.1 FOX gene cluster, the interesting question remains: why does FOXF1 inactivation result in intestinal malrotation, but deletion of the entire FOX cluster result in gastro-intestinal atresias, whereas Foxf1 inactivation in mice results in esophageal atresia? This evidence concerns the gene FOXF1 and Esophageal atresia.