Several large randomized controlled trials were stopped due to unacceptably high rates of severe hypoglycemia (blood glucose (BG) <2.2 mmol/L), 9.8% of patients in the Glucontrol study [9] and 17.0% of the tight control group in the Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP) study [10]. This evidence concerns the gene INS and Hypoglycemia.