Since oxidized LDL induces expression of a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, gp91phox, and ROS generation in vascular endothelial cells [28], ezetimibe may attenuate ROS production through reduction of circulating ox-LDL in patients with hypercholesterolemia. The gene discussed is CYBB; the disease is familial hypercholesterolemia.