ANGPT1 and neoplasm: To determine that angiopoietins from IFN/5-FU-treated tumor cells mediated the observed proliferative and apoptotic effects, we evaluated whether endogenous expression of Ang-1 and Ang-2 are required anti-proliferative effects of the supernatants of IFN/5-FU treated HuH-7 cells using Ang-1 and Ang-2 siRNAs.