Furthermore, infection of endometrial adenocarcinoma explants (Fig. 6E; P < 0.001) using RCAN1-4 adenovirus significantly reduced the PGF2α-FP receptor induction of CXCL8 mRNA expression compared to tissue infected with the scrambled control virus similar to our in vitro data using Ishikawa FPS cells. Here, CXCL8 is linked to endometrium adenocarcinoma.