RCAN1 and endometrium adenocarcinoma: Furthermore, infection of endometrial adenocarcinoma explants (Fig. 6E; P < 0.001) using RCAN1-4 adenovirus significantly reduced the PGF2α-FP receptor induction of CXCL8 mRNA expression compared to tissue infected with the scrambled control virus similar to our in vitro data using Ishikawa FPS cells.