CXCL8 and endometrium adenocarcinoma: Moreover we have shown that CXCL8 expression in endometrial adenocarcinoma explants is negatively regulated by RCAN1-4 since infection of endometrial adenocarcinoma explants with RCAN1-4 adenovirus abolished the PGF2α-FP receptor-mediated induction of CXCL8.