Taken together, our data (as summarised in Fig. 8) show that PGF2α-FP receptor activation in endometrial adenocarcinoma cells promotes the activation of RCAN1-4 and CXCL8 via the Gq-PLC-PKC–calcium–calcineurin–NFAT. This evidence concerns the gene HSPG2 and endometrium adenocarcinoma.