NFKB1 and fibrosarcoma: Several studies have documented that the suppression of IκBα could induce NF-κB nuclear translocation and consequently promote the increase of MMP-2 in several types of human cells including Ewing sarcoma EW7 cells [20], human skin cells [21], murine melanoma cells [22], and HT1080 (fibrosarcoma) cells [23].