TLR4 and Sepsis: Lipopolysaccharide (LPS), the Gram-negative bacterial outer membrane glycolipid, induces sepsis through its interaction with LPS-binding protein (LBP) or CD14 prior to subsequent formation of a complex with myeloid differentiation protein-2 (MD-2) and Toll-like receptor 4 (TLR4) [2]–[12].