Furthermore, elucidation of the mechanism by which canonical Notch signaling is manipulated by KSHV in LEC raises the possibility that KS may be susceptible to treatment with the NOTCH1 Decoy [86], an inhibitor of NOTCH1 and NOTCH4 signaling, shown to be effective in neuroblastoma and mouse mammary carcinoma xenografts. Here, NOTCH4 is linked to neuroblastoma.