CDKN2A and neoplasm: The immunologic significance of a tumor expressing RCAS antigens has yet to be addressed, and because all of these models share the common trait of utilizing germline INK4a/Arf deletion to promote glial neoplasms, there are undoubtedly additional immunologic consequences of these models that would not be encountered in patients where INK4a/Arf inactivation was limited to tumor cells only.