One significance of this observation was revealed by Xiao and colleagues who reported that crossbreeding PTEN +/- mice with a strain containing a GFAP driven truncated SV40 T antigen resulted in Rb, p107, and p130 (but not p53) inhibition, and significantly accelerated the development of GBM in the double transgenic progeny [54]. Here, PTEN is linked to glioblastoma.