Additionally, we found down-regulated Rho guanine nucleotide exchange factors such as ArhGEF15 (Rho guanine nucleotide exchange factor 15) (−9.4-fold adenocarcinoma vs transgenic/−10.7-fold adenocarcinoma vs non-transgenic), ArhGEF10 (Rho guanine nucleotide exchange factor 10) (−5.1-fold adenocarcinoma vs transgenic/−6.3-fold adenocarcinoma vs non-transgenic) and the Rho GTPase activating protein, ArhGAP20 (Rho GTPase activating protein 20) (−6.0-fold adenocarcinoma vs transgenic/−8.5-fold adenocarcinoma vs non-transgenic) to be repressed. Here, ARHGEF15 is linked to adenocarcinoma.