Therefore we searched for regulated growth factors and their receptors and observed 5 genes to be up-regulated ranging between 6.3-26.6-fold, e.g. Areg (amphiregulin), Ereg (epiregulin), and up to 70 genes down-regulated (−3.8 to −29.4-fold), e.g. Fgf7 (fibroblast growth factor 7), Fgfr4 (fibroblast growth factor receptor 4), Pdgfb (platelet-derived growth factor beta polypeptide)), Vegfd/Figf (c-fos induced growth factor) and Vegfr2/Kdr (vascular endothelial growth factor receptor- 2) when transgenic but morphologically unaltered lung tissue was compared with adenocarcinomas. This evidence concerns the gene FGFR4 and adenocarcinoma.