Expression of the tumor suppressors mutated in colorectal cancers (Mcc), hairy/enhancer-of-split related with YRPW motif 1 (Hey1), FAT tumor suppressor homolog 3 (Fat3), armadillo repeat containing, X-linked 1 (Armcx1) and reversion-inducing-cysteine-rich protein with kazal motifs (Reck) was significantly up to −14.0-fold repressed in adenocarcinomas. The gene discussed is FAT3; the disease is Merkel cell skin cancer.