Next to the homeobox genes we found members of the transcription factors belonging to the SRY-related HMG (High Mobility Group) box superfamily down regulated in adenocarcinoma e.g. Sox7, Sox11 and Sox13 were repressed by −4.9 to −80.6 and −4.3-fold in adenocarcinoma compared with transgenic and −5.6 to −101.0-fold in adenocarcinoma versus non-transgenic. Here, SOX11 is linked to adenocarcinoma.