We found Chl1 (cell adhesion molecule with homology to L1CAM) a member of the L1 gene family of neural cell adhesion molecules as 20.4-fold up-regulated but up to 50 genes were down-regulated, e.g. Icam2 (intercellular adhesion molecule 2) (−9.4-fold), Pecam1 (platelet/endothelial cell adhesion molecule 1) (−5.4-fold), Sell (selectin, lymphocyte) (−8.6-fold), Cdh5 (cadherin 5) (−8.4-fold), Itga1 (integrin alpha 1) (−4.0-fold) and Itga8 (integrin alpha 8) (−16.1-fold) in adenocarcinoma vs transgenic cells. The gene discussed is PECAM1; the disease is adenocarcinoma.