JAK3 and neoplasm: In addition, our results demonstrating theaflavin-induced protection of IL2Rγc/Jak-3/Stat-5A signaling as well as survival of CD4+ T cells from tumor PGE2-insult signify that these plant polyphenols may have the potency to sustain the cell mediated immunity of the cancer-bearer that can be utilized for developing an effective therapy of this deadly disease.