This 1,679-person analysis of the US HIV Outpatient Study cohort found that a CD4 count under 350 cells/mm3 when first measured independently raised the risk of new cardiovascular disease more than 75% [5] Additional evidence supporting the clinical value of earlier intervention with antiretrovirals could lead World Health Organization (WHO) advisors to review guidelines on when to start ART in resource-limited countries. The gene discussed is CD4; the disease is cardiovascular disorder.