SCARB1 and age-related macular degeneration: However, the distribution of the SCARB1 rs5888 genotype was significantly different in the North American AMD population compared to controls (p<0.004): CT heterozygotes were at increased risk of AMD compared to CC subjects (adjusted ORCT vs CC = 1.4, 95%CI 1.0–1.8), TT did not significantly differ from CC (adjusted OR = 1.2 CI95% 0.9–1.7).Similar results were obtained after pooling the French and the North American population: adjusted ORCT vs CC = 1.3, 95%CI: 1.0–1.7) and adjusted ORTT vs CC = 1.2, 95%CI 0.9–1.7.