GSR and hyperinsulinemic hypoglycemia, familial, 4: In view of (a) the potentially similar metabolic effects of G6PD and GR deficiency, (b) the well documented protection from severe falciparum malaria afforded by G6PD deficiency [14], [19] and (c) the fact that P. falciparum GR and human GR represent most promising antimalarial drug targets, we studied invasion and growth of several P. falciparum strains in GR-deficient RBCs as well as the stage-dependent pathological alterations induced by parasite growth in these erythrocytes.