Interestingly, all BRCA2 mutations of our series were detected in the subset of patients originating from North Sardinia (4/91; 4.4%); one BRCA2-positive case was among 4 patients with familial recurrence of melanoma, whereas the remaining three (3.4%) BRCA2-positive cases were among 87 patients with sporadic melanoma (Table 2). This evidence concerns the gene BRCA2 and melanoma.