Two MC1R germline variants classified as "R", Arg151Cys [odds ratio (OR), 6.4; 95% confidence interval (95% CI), 2.1-15.9] and Asp294 His (OR, 1.8; 95% CI, 1.1-5.3), were significantly associated with melanoma in our series (Table 3). Here, MC1R is linked to melanoma.