Overall the data reported herein suggest that the events leading to islet-damaging autoimmune destruction might be rooted to early processes, some sharing common characteristics with several other inflammatory conditions found also in microbes-hosting tissues (i.e. Pla2g1b, Mt1) and in certain cancers (i.e. Klk genes, Muc1, Reg genes). Here, PLA2G1B is linked to cancer.