Interestingly, patients with Sjogren's syndrome/sicca symptoms were more likely to have lower IL-8 (odds ratio = 0.89, 95% confidence interval = 0.81 to 0.99) and IL-1β (odds ratio = 0.75, 95% confidence interval = 0.63 to 0.88). This evidence concerns the gene CXCL8 and Sjogren syndrome.