Known human neurological disorders associated with the networks, particularly network 2, include X-linked lissencephaly (Online Mendelian Inheritance in Man [OMIM:300067]; DCX), juvenile onset dystonia ([OMIM:607371]; ACTB) and Beckwith-Wiedemann syndrome ([OMIM:130600]; CDKN1C). The gene discussed is ACTB; the disease is lissencephaly type 1 due to doublecortin gene mutation.