Given the reported associations to classical lipids and cardiovascular disease with variants at the FADS1–3 locus [10],[13],[14], and the evidence from functional studies of a role for sphingolipids in atherosclerotic plaque formation and lipotoxic cardiomyopathy [15], we looked in silico in a series of three age- and sex-adjusted GWAS datasets of German myocardial infarction (MI) case-control studies (Ger MIFS I [16] Ger MIFS II [17] and Ger MIFS III (KORA), unpublished) for evidence of association with the major variants associating with sphingolipid concentrations. Here, FADS1 is linked to cardiovascular disorder.