The identification of LRP (Rpsa), better known as the 37-kDa/67-kDa laminin receptor in the prion research field and currently under investigation as a therapeutic target for prion disease [53],[54],[55], corroborated previous experiments documenting its spatial proximity to PrPC (and possibly Dpl [56],[57]) and was complemented by the identification of ribosomal protein S21 (Rps21), a protein which not only can bind to LRP but shares with the latter the ability to exert a ribosome-independent function at the plasma membrane [58],[59]. Here, RPSA is linked to prion disease.