IRF3 and infection: Analogously, DKO Mφ supported increased WNV replication (∼35, 250 and 310-fold, P<0.0001 at 24, 48 and 72 h after infection, respectively) compared to wild type or even IRF-3−/− or IRF-7−/− singly deficient cells (Fig 5A and [21],[22]).