The advantages of tumor targeted delivery of combined IL-12 and IL-27 in PC would be the modulation of the tumor microenvironment not only through their known effect on resident antigen presenting cells (and therefore on the de-novo priming of new Th1 effectors in the draining lymph nodes) but also directly on the modulation of the cytokines secreted by Th2 GATA-3+ infiltrating T cell effectors already present in the tumor by diminishing their negative effects on fibrinogenesis and recruitment of immunosuppressive myeloid dendritic cells, in the absence of systemic toxicity. Here, GATA3 is linked to neoplasm.