In agreement with the Th2 skew observed in circulating CEA specific CD4+ T cells, immunohistochemical analysis of tumor infiltrating lymphocytes showed a significantly higher number of GATA-3+ (Th2) compared to T-bet+ (Th1) lymphoid cells, supporting a Th2 skew also at the tumor site. The gene discussed is CEACAM5; the disease is neoplasm.