IL27 and neoplasm: The advantages of tumor targeted delivery of combined IL-12 and IL-27 in PC would be the modulation of the tumor microenvironment not only through their known effect on resident antigen presenting cells (and therefore on the de-novo priming of new Th1 effectors in the draining lymph nodes) but also directly on the modulation of the cytokines secreted by Th2 GATA-3+ infiltrating T cell effectors already present in the tumor by diminishing their negative effects on fibrinogenesis and recruitment of immunosuppressive myeloid dendritic cells, in the absence of systemic toxicity.