In addition, BER showed the synergistic effects with the existing anticancer agents celecoxib (the inhibitor of COX-2), trichostatin A (TSA, the histone deacetylase inhibitor), and carmofur (KA or K) against the growth of MDA-MB-231 cells, which enhanced inhibitory rate of the cancer cell growth more than twice. This evidence concerns the gene PTGS2 and cancer.