Rather, these are the products of dead-end escape-routes whereby cells, in the case of AD pyramidal neurons in limbic brain regions, attempt to limit the negative impact of accumulating misfolded and aggregated proteins that cannot be properly handled by normal cellular proteolytic degradation mechanisms, i.e. endosomal, lysosomal, auto-phagosomal, proteasomal, ... It is then not surprising to see many of these involved in, or attained by, the amyloid or tau pathology. This evidence concerns the gene MAPT and Alzheimer disease.