As shown in Fig. 2A (right panel), ATIP3 knock-down by both siRNAs led to a significant increase (66.4±5.3% and 63±10.2% upon transfection of siRNA#1 and siRNA#2, respectively) in MDA-MB-468 breast cancer cell proliferation, pointing to an anti-proliferative effect of ATIP3. Here, MTUS1 is linked to breast cancer.