Patients suffering from familial adenomatous polyposis have a higher chance of developing duodenal adenocarcinoma.[1] These patients have high frequency of p53 overexpression.[2] Hereditary nonpolyposis colorectal cancer patients have a high likelihood of developing adenocarcinoma of the small bowel.[3] Environmental factors such as a diet rich in red meat, salt-cured or smoked foods, as well as intake of tobacco and alcohol, have been implicated in the etiology of this malignancy.[4]. The gene discussed is TP53; the disease is duodenal adenocarcinoma.