According to the multistep route of genetic alterations in the colorectal adenoma-carcinoma sequence, the K-ras mutation is one of the first alterations to occur.[5] p53 mutations are the most frequently detected genetic alteration in human cancer.[8, 9] Mutations in the p53 tumor suppressor gene are identified in approximately 35-45% of CRCs[10–13] whereas activating mutations in the K-ras proto-oncogene are seen in 25-60% of CRCs.[5, 14]. The gene discussed is TP53; the disease is cancer.