Recently, some authors have proposed three additional subtypes of nondysplastic hyperplastic polyps with normal architecture and proliferation based on degree of serration, content of cytoplasmic mucin, and the number of goblet cells: Microvesicular type, goblet cell–rich type and mucin-poor type.[17] The microvesicular type is the most common type and there is some evidence that this type may rarely progress to carcinoma.[12, 18, 19] Therefore, general surgical pathologists may need to be aware of this subclassification as it might be clinically significant. The gene discussed is MUC5AC; the disease is hyperplastic polyp.