We have examined possible changes in levels of GRP78 and other markers of ER stress in breast cancer cells treated with TAIII, An induction in levels of GRP78 and TRIB3 was observed in MDAMB231 cells but not in BT474 cells (Figure 5B), indicating a weak or possibly atypical ER stress response in the latter. The gene discussed is TRIB3; the disease is breast cancer.