Given the inconsistency of these previous findings, the aim of the present study was to examine the possible impact of the type 2 diabetes predisposing variants in or near JAZF1, CDC123/CAMK1D, TSPAN/LGR5, THADA, ADAMTS9, and NOTCH2 loci on pancreatic beta-cell function and insulin sensitivity in non-diabetic European offspring of type 2 diabetic patients, who had been examined with an OGTT and an intravenous glucose-tolerance test (IVGTT). This evidence concerns the gene TSPAN18 and type 2 diabetes mellitus.