INS and diabetes mellitus: Homozygous carriers of the minor diabetes-associated G-allele of the CDC123/CAMK1D rs12779790 showed an 18% decrease in insulinogenic index, an 18% decrease in corrected insulin response (CIR), and a 13% decrease in the ratio of area under the serum insulin and plasma glucose curves during an OGTT (AUC-insulin/AUC-glucose) [7].