OGG1 and glioblastoma: Similarly, it was recently reported that in malignant tissues (in transitional meningioma and in glioblastoma multiforme) the degree of oxidative DNA damage (8OHdG) is increased whereas the total anti-oxidant capacity is decreased (Hanimoglu et al, 2007; Tuzgen et al, 2007) Indeed, efficient DNA repair mechanisms comprise a critical component in the protection against cancer and among these the 8-oxoguanine DNA glycosylase (OGG1) enzyme is crucial for repairing the oxidative DNA lesion 8OHdG that is highly mutagenic and carcinogenic.