To examine further the utility of urinary cathepsin D as a pre-operative marker, the association of cathepsin D with the variables used in the pre-operative nomogram developed by Karakiewicz et al (n=2474) (Karakiewicz et al, 2009), that is CT tumour size, CT T stage and symptoms at presentation was also examined (Table 3). Here, CTSD is linked to neoplasm.