UKF-NB-3, [see additional file 6]) encodes for a protein also called protein kinase B (PKB) that is a central mediator of survival signals transduced by the phosphatidylinositol 3-kinase and is involved in chemoresistance [55-57] as well as in cancer cell expression of pro-angiogenic factors [58-60]. This evidence concerns the gene AKT1 and cancer.