CXCR4 and melanoma: It was reported that an excessive expression of CXCR4 on B16 melanoma cells enhances the metastatic accumulation of the cells in mouse lung, and that a CXCR4 antagonist T22 blocks pulmonary metastasis in mice injected with CXCR4-transduced B16 cells (Murakami et al. 2002).