We have previously demonstrated that overexpression of TPPII in Burkitt’s lymphoma or transfected HEK293 cells correlates with accelerated proliferation and with the accumulation of centrosome and chromosome aberrations, whereas functional knockdown of TPPII by shRNA results in growth retardation and the accumulation of polynucleated cells that fail to complete cell division (Stavropoulou et al. 2005). The gene discussed is TPP2; the disease is Burkitt lymphoma.