Once established that deregulation of the TGF-β signalling pathway is implicated in head and neck tumorogenesis (Prime et al. 2004; Derynck et al. 2001; Paterson et al. 2001; Rosenthal et al. 2004; Wang et al. 1997; Garrigue-Antar et al. 1995; Lu et al. 2004; Muro-Cacho et al. 1999; Pasche, 2001), the particular mechanisms which TAK1 employs to modulate the tumor cell behaviour in the HNSCC case have to be uncovered. Here, TGFB1 is linked to neoplasm.