To test the genetic requirements of this tumor-like phenotype, we screened a small collection of alleles of signaling, polarity, and growth regulatory genes (stat92E, crb, lgl, Drosophila aPKC, yki, cyclinD, dMyc, s6k and others) for their ability to suppress size and/or architectural phenotypes associated with loss of ept/tsg101. Here, RPS6KB1 is linked to neoplasm.