More recent work showing that the TSG101 gene is overexpressed in some human cancers [17]–[19] and that transgenic overexpression of TSG101 in the mouse mammary gland mildly increases the frequency of breast carcinoma [17] tends to support the idea that excess TSG101 promotes, rather than inhibits, cell survival and proliferation. The gene discussed is TSG101; the disease is breast carcinoma.