Screening for two candidate genes (MATN1 and LAPTM5) on this BAC revealed that the expression of LAPTM5 was down-regulated in NB cell lines and the CG sites around the transcriptional start site (TSS) of this gene were highly and widely methylated in both NB cell lines and primary NB tumors (Supplementary Figure S1, Supplementary Table S1, and Supplementary Methods S1), prompting us to focus on LAPTM5 as a candidate for an NB-related gene down-regulated through DNA methylation. Here, LAPTM5 is linked to neuroblastoma.