In addition, the immunostaining of cleaved caspase-3 revealed that LAPTM5-positive degenerating NB cells were essentially negative at least when the cleaved caspase-3 was present in SH-SY5Y cells induced into apoptosis by treatment with Cisplatin (CDDP) (Figure 2C), suggesting that caspase-independent cell death might occur in LAPTM5-positive degenerating NB cells. Here, CASP3 is linked to neuroblastoma.