The positive expression combined with the p53+Ki-67 markers was also positive in 50% of the total number of cases, but only in 28.6% (4 cases) of the cases with lymph node metastasis had p value of 0.023 for this relationship, however the Fisher's exact was higher than 0.05 (f = 0.056). The gene discussed is MKI67; the disease is metastatic malignant neoplasm in the lymph nodes.