CCND1 and cancer: The molecular mechanism of SHetA2 induction of apoptosis in cancer cells is associated with decreases in Bcl-2 and Bcl-xl levels (Liu et al. 2007a), while G1 cell cycle arrest is associated with decrease of Cyclin D1 levels (Masamha, 2007; Liu et al. 2007b) and induction of differentiation is associated with increase of E-Cadherin expression (Liu et al. 2007b).