It is the glycoprotein of the virion that binds to the EBV receptor CD21 (or complement receptor type II, CR2) and initiates infection ([8], [46].The another glycoprotein, gp110 encoded by EBV BALF4 ORF is expressed during the lytic phase of EBV not only at nuclear membrane but also at the cellular membrane and has been shown genetically to be essential for virus maturation [47], [48], [49]. The gene discussed is CR2; the disease is infection.