Also, given that common variants in the NLRP3 region have previously been associated with CD [3] and that the gene products of NLRP3 and MEFV (i.e. NALP3 and pyrin, respectively) are known to interact together in the inflammasome molecular platform [16]–[18], we also perform gene-gene interaction analysis between common variants in the MEFV and NLRP3 region to assess whether such interactions could have masked the MEFV contribution to CD pathogenesis. Here, NLRP3 is linked to Cowden disease.