MEFV and Cowden disease: To assess the reproducibility of these results, we subsequently evaluated the association of the same 12 tagging SNPs and the 4 coding SNPs located in MEFV exon 2 region (i.e. rs224225, rs224224, rs224223, and rs224222) in additional samples from Canada (256 CD trios, 91 UC trios) and Scotland (495 UC, 370 controls) (Table 1).