We hypothesized that the factors involved in fibroblast-to-myofibroblast transdifferentiation, such as tumour-cell-derived TGF-β1, promote the generation of intercellular ROS, which in turn acts as a signalling molecule, and initiates up-regulation of CLIC4 expression, thus triggering fibroblast-to-myofibroblast conversion. This evidence concerns the gene TGFB1 and neoplasm.