In this study, we showed that treatment of myofibroblasts with agents blocking ROS or CLIC4 can reverse the phenotype of myofibroblasts, and markedly repress the production of angiogenesis factors associated with myofibroblast transdifferentiation, indicating that ROS or CLIC4 are excellent targets for the development of targeted molecular therapies for the treatment of ovarian cancer. This evidence concerns the gene CLIC4 and ovarian carcinoma.