To test the hypothesis, we designed an experiment modelling ovarian cancer fibroblast-to-myofibroblast transdifferentiation and examined the pathway in which ROS and CLIC4 participates in fibroblast-to-myofibroblast transition induced by TGF-β1 or conditioned media from ovarian cancer SKOV3 cells (CMSKOV3). Here, CLIC4 is linked to ovarian cancer.