Whether IL-10 levels reflect Treg activity, it is intriguing to speculate that the patients with decreased IL-10 responses (thereby defective down regulation of Th1 and Th2 responses) could have greater inflammatory response to viral infections (e.g. to >150 circulating RV strains) [9, 10] and thereby increased risk for recurrent wheezing. The gene discussed is IL10; the disease is viral infectious disease.