The elevated levels of IFN-gamma, IL-13 and IL-10 (pre-existing or virus-induced) in RV-affected children underline the importance of these cytokines in the early pathogenesis of asthma and the detection of RV as an important, maybe not a risk factor, but a revealing factor for a high risk phenotype [5–8, 17, 26]. This evidence concerns the gene IL13 and asthma.