IL10 and arthritic joint disease: We have reported that the L19 antibody, specific to the alternatively spliced extra-domain B (EDB) of fibronectin [16,17], could be fused to human IL10, thus generating an immunocytokine capable of preferential accumulation at neovascular sites of cancer and arthritis and capable of inhibiting the progression of established collagen-induced arthritis (CIA) in the mouse [18].