To analyze whether expression of MS4A12 is under control of CDX transcription factors, we expressed luciferase reporter genes directed by the wild type MS4A12 promoter domain (-952 to +12) or by five promoter variants, each mutated at one of the putative CDX binding sites, in MS4A12-positive LoVo colon cancer cells. The gene discussed is MS4A12; the disease is malignant colon neoplasm.